Williamson ether synthesis (Alkoxide + good LG on primary/ methyl substrate → ether (SN2 on carbon))
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Alkoxide + good LG on primary/ methyl substrate → ether (SN2 on carbon)
What each symbol means
| Symbol | What it stands for |
|---|---|
| R'X | Usually 1° or methyl halide (or sulfonate) |
| RO⁻ | Alkoxide nucleophile |
When to use this
Polar aprotic or suitable solvent; avoid β-branched halides for Williamson; competitive elimination if R'X is 2°/3°.