Hofmann elimination regioselectivity (bulky base) (E2 on quaternary ammonium; bulky base removes β-H from less hindered carbon (Hofmann)
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E2 on quaternary ammonium; bulky base removes β-H from less hindered carbon (Hofmann product)
What each symbol means
| Symbol | What it stands for |
|---|---|
| R₄N⁺OH⁻ | Hofmann elimination precursor (exhaustive methylation pathway in textbooks) |
When to use this
Strong bulky base (e.g., t-BuOK) or Hofmann elimination conditions; opposite regioselectivity to Zaitsev in many comparisons.