Hofmann bromamide degradation (primary amide → 1° amine, one fewer carbon) (Primary amide treated with Br₂/NaOH gives primary amine with loss of carbonyl carbon as)
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Primary amide treated with Br₂/NaOH gives primary amine with loss of carbonyl carbon as carbonate
What each symbol means
| Symbol | What it stands for |
|---|---|
| RCONH₂ | Primary amide only (1° amide N-H) |
When to use this
Aqueous base; bromine; isocyanate intermediate in mechanistic teaching; carbon count drops by one at the carbonyl carbon.